Novel lattice SIM technology enables superresolution of living samples
ZEISS Elyra 7 with Lattice SIM is a microscope system for superresolution imaging in biomedical research. Its novel Lattice SIM technology is extremely light-efficient and fast. Researchers profit from less photodamage and high imaging speed. Lattice SIM illumination pushes the boundaries of fast superresolution as it now can be used for almost all imaging experiments with live and fixed specimens. As a result, fast processes in living samples can be examined gently, with a large field of view, in 3D, over long periods of time and in two colors simultaneously.
Understanding lattice SIM technology
Lattice SIM provides optical sectioning and a doubling of diffraction-limited resolution in 3D. The Lattice SIM technology improves on the classic principle of superresolution structured illumination microscopy (SR-SIM), making it possible to achieve an image acquisition rate of up to 255 frames per second (fps). Additionally, the high illumination pattern contrast and robust reconstruction allow for imaging in deeper or more scattering tissue.
The achievable spatial resolution and frame rate of ZEISS Elyra 7 can be precisely matched to the requirements of the experiment. The unique technology allows to overcome speed-, 3D- and photodamage-limitations of classic SIM systems and opens the door to new discoveries in many areas of life sciences.
Learn more in this technology note.
About the R&D 100 Awards
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